Institution of Mechanical Engineers IMechE

Smith & Nephew Lecture - Individualised multiscale modelling to predict risk of bone fracture in osteoporotic patients

28 February 2013

This lecture will present the main results of a four year research project (VPHOP) devoted to the development and assessment of a new technology that uses computer models of the musculoskeletal biomechanics, individualised over imaging and sensing data, to predict the risk of bone fracture in fragile elders affected by a metabolic disease called osteoporosis. The results suggest that it is possible to capture the complexity of this pathological condition by means of an hypermodel, an orchestration of biomechanical and mechanobiological models each capturing the process at one characteristic space-time scale. Despite its complexity this technology can be deployed in a real world clinical setting.

Marco Viceconti has a Mechanical Engineering degree from the University of Bologna and a PhD from the University of Firenze. He was the Technical Director of the Medical Technology Lab at the Rizzoli Orthopaedic Institute in Bologna, Italy before moving to the University of Sheffield where he is full Professor of Biomechanics at the Department of Mechanical Engineering. He is also Scientific Director of the Insigneo/Sheffield Research Institute.

His main research interests are related to the development and validation of medical technology, especially that involving simulation, and primarily in relation to musculoskeletal diseases. He has published over 200 papers and is a past President of the European Society of Biomechanics. Prof. Viceconti is one of the key figures in the emerging Virtual Physiological Human (VPH) community. Co-author of the first white paper on VPH, scientific coordinator of the seminal VPH research roadmap and coordinator of one the VPHOP integrated projects, he is also currently chairing the Board of Directors of the VPH Institute.

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